GCN2 — Saccharomyces cerevisiae S288c

Summary

YDR283C, also known as GCN2 in Saccharomyces cerevisiae S288c, encodes a protein with histidine-tRNA ligase activity, eukaryotic translation initiation factor 2alpha kinase activity, 3-phosphoinositide-dependent protein kinase activity, protein serine/threonine kinase activity, and phospholipid binding. This gene is associated with tRNA charging, response to amino acid starvation, regulation of translation, and downregulation of translation initiation in response to stress. It is linked to responses to virus, diamide, and oxidative stress, as well as salt sensitivity. Phenotypic associations include increased chronological and replicative lifespan, decreased pseudohyphal growth and biofilm formation, delayed cell cycle progression through the G1/S phase transition, and effects on vegetative growth, competitive fitness, and resistance to various chemicals. The gene product localizes to meiotic spindle pole bodies, septin rings, and cellular bud necks.