ZIP1 — Saccharomyces cerevisiae S288c

Summary

YDR285W (ZIP1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein of unknown molecular function, with no enzyme class or molecular-function terms annotated. The gene is associated with meiotic processes, including pachytene, leptotene, zygotene, prophase, and meiosis I, as well as the pachytene checkpoint, DNA damage checkpoint, and meiotic cell cycle control. It is linked to homologous recombination, meiotic mismatch repair, sister chromatid cohesion, and anaphase. Associations with zinc transport and import, and responses to SCF, are also noted. Phenotypic evidence connects ZIP1 to abnormal or decreased meiotic recombination, abnormal meiosis and chromosome segregation, decreased sporulation and spore germination, and decreased transposable element transposition. The gene is further associated with zinc concentration and oxidative stress traits.