HMO1 — Saccharomyces cerevisiae S288c

Summary

YDR174W in Saccharomyces cerevisiae S288c encodes an HMGB family protein with DNA binding, bending, and Holliday junction binding activity. The gene is associated with numerous nuclear processes including homologous recombination, DNA replication, DNA topological change, regulation of transcription by RNA polymerases I and II, ribosomal protein gene transcription, rRNA processing, ribosome biogenesis, and rDNA packaging. It localises to the nucleolus, SSU processome, rDNA heterochromatin, and cytosol. Phenotypic associations link YDR174W to cell cycle control, particularly negative regulation of G1/S transition and delayed G1 phase progression, as well as increased telomere length, altered budding pattern, and abnormal colony appearance. The gene is associated with stress responses including altered resistance to oxidative stress, freeze-thaw, desiccation, heat, cold, hyperosmotic stress, and metal toxicity, alongside effects on fermentative growth, vegetative growth, nitrogen source utilisation, and chemical compound accumulation.