UME6 — Saccharomyces cerevisiae S288c

Summary

YDR207C in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription activator with a Zn2-C6 fungal-type DNA-binding domain, localising to the nucleus. The gene is associated with response to inositol and starvation, spore wall assembly and germination, NAD and phospholipid anabolism, macroautophagy, meiosis activation, and regulation of cell growth. Phenotypic associations link YDR207C to absent sporulation and spore germination, increased mutation frequency, delayed meiosis, decreased stress resistance including oxidative, osmotic, UV, and desiccation tolerance, reduced chronological lifespan, decreased respiratory growth, and altered carbon and nitrogen source utilisation. The gene is also associated with calcium sensitivity, increased chitin deposition, abnormal lipid particle morphology, and decreased alkaline pH resistance. Studies of related genes in other species have linked the family to reduced virulence.