UPC2 — Saccharomyces cerevisiae S288c

Summary

YDR213W (UPC2) on chromosome IV of Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor specific to RNA polymerase II, belonging to the Zn2-C6 fungal-type DNA-binding superfamily and the sterol uptake regulator family. The gene is associated with sterol depletion response, response to sterol, intracellular sterol transport, sterol import, regulation of sterol import, cholesterol import, ergosterol anabolism, lipid storage and homeostasis, terpene and geranyl diphosphate anabolism, lipoprotein anabolism, pyroptotic cell death, response to anoxia, and NO storage. It is linked to increased pseudohyphal and invasive growth, abnormal budding index, cell cycle progression in G1 phase, cellular morphology, colony appearance, vacuolar morphology, and cell size, as well as decreased chronological lifespan, vegetative growth, oxidative stress resistance, metal resistance, competitive fitness, and altered chemical compound accumulation and apoptosis. Studies of related genes in other species link the family to reduced virulence.