STE5 — Saccharomyces cerevisiae S288c

Summary

YDR103W, also known as STE5 in Saccharomyces cerevisiae S288c, encodes a scaffold protein. The gene is associated with a wide range of biological processes, including pheromone response and breakdown, mating behavior, cell-cell fusion, chemotropism, signal transduction, regulation of kinase activity, and protein kinase A activation. It is also linked to retrotransposition, sphingolipid anabolism, phototransduction, plasma membrane fusion, chemotaxis, and nitric oxide signaling. Phenotypic associations include sterility, absence of shmoo formation and mating response, decreased pheromone production and mating efficiency, altered pheromone sensitivity, and impaired cell cycle arrest. The gene is further connected to decreased replicative lifespan, altered metal and chemical resistance, reduced UV resistance, and abnormal vegetative growth and competitive fitness.