INO2 — Saccharomyces cerevisiae S288c

Summary

YDR123C in Saccharomyces cerevisiae S288c encodes a basic helix-loop-helix (bHLH) domain-containing protein, placing it in the HLH DNA-binding superfamily. The gene is annotated to a wide range of biological processes, including inositol and phospholipid anabolism, lipogenesis and lipolysis, glycerolipid metabolism, terpene and lycopene anabolism, glycine breakdown, sulfate assimilation, retinol transport, TOR signaling, and membrane biogenesis. It is also associated with lipid homeostasis, triglyceride storage, and dephosphorylation. Phenotypically, YDR123C is linked to abnormal budding index, cell cycle progression in G1 phase, endoplasmic reticulum and vacuolar morphology, decreased sporulation and vegetative growth, altered stress and starvation resistance, and changes in chemical compound accumulation. The gene is further associated with oxidative stress and is related to INO2.