HSP42 — Saccharomyces cerevisiae S288c

Summary

YDR171W in Saccharomyces cerevisiae S288c encodes a protein belonging to the HSP20-like chaperone family, characterized by an A-crystallin/Hsp20 domain. The gene is associated with protein quality control processes including proteaphagy, aggrephagy, protein refolding, and protein denaturation, as well as cellular thermotolerance, oxidative stress, and innate immunity. It is linked to mRNA stabilization, DNA replication, proteasome assembly, mitotic spindle organization, mycose biosynthesis, the glyoxylate cycle, translation, and translation termination. Phenotypic associations include decreased mitotic recombination and protein accumulation, abnormal protein distribution, haploinsufficiency, increased competitive fitness, and altered chemical resistance. The related gene HSP42 shares functional connections.