LYS14 — Saccharomyces cerevisiae S288c

Summary

YDR034C, also known as UPC2 or LYS14 on chromosome IV of Saccharomyces cerevisiae, encodes a DNA-binding transcription factor with RNA polymerase II-specific activity, a C6 zinc-finger DNA-binding domain, and zinc-binding capability. It is localized to the nucleus. The gene is associated with the regulation of sterol import, cholesterol import, ergosterol biosynthesis and metabolism, steroidogenesis, the diaminopimelate and lysine biosynthesis pathways, terpene and geranyl diphosphate biosynthesis, the response to anoxia and sterol depletion, pyroptotic cell death, and carbohydrate breakdown. It has been linked to increased innate thermotolerance, increased invasive growth, altered chemical compound accumulation, decreased vegetative growth rate, decreased competitive fitness, and altered resistance to chemicals. Studies of related genes in other species link the family to reduced virulence.