ARF1 — Saccharomyces cerevisiae S288c

Summary

YDL192W in Saccharomyces cerevisiae S288c encodes a protein membrane adaptor with GTPase activity and GTP binding, belonging to the Arf1-5-like small GTPase family. It is associated with cisternal maturation, membrane organization, COPI vesicle budding, vesicle uncoating, clathrin coat assembly, intracellular transport, mitophagy, calcium signaling, and response to stress. The protein localizes to ER exit sites, COPII vesicle coats, Golgi and ER membranes, microtubule cytoskeleton, and cell cortex. Phenotypic associations link the gene to abnormal Golgi and ER morphology, decreased protein secretion, reduced replicative and chronological lifespan, increased heat sensitivity, altered metal and toxin resistance, decreased desiccation resistance, and reduced vegetative growth rate. It is also associated with potassium concentration and oxidative stress. Related genes in other species connect the family to small GTPase-mediated vesicular transport.