TRP1 — Saccharomyces cerevisiae S288c

Summary

YDR007W (TRP1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with phosphoribosylanthranilate isomerase activity, indole-3-glycerol-phosphate synthase activity, and anthranilate synthase activity, placing it in the TrpF family with a ribulose-phosphate binding barrel domain. The gene is associated with tryptophan formation, amino acid import, and amino acid anabolism, as well as diverse processes including double-strand break repair, cytokinesis, glycosylation, vacuolar protein sorting, and responses to yeast and SDS. It is linked to traits such as oleic acid content, salt sensitivity, and acid sensitivity. Phenotypic associations include decreased cold sensitivity, gamma ray resistance, hydrostatic pressure resistance, alkaline pH resistance, and hyperosmotic stress resistance, alongside increased chronological lifespan, innate thermotolerance, and chemical resistance, with auxotrophy and decreased vegetative growth also noted. The protein localizes to the cytosol.