SSB1 — Saccharomyces cerevisiae S288c

Summary

YDL229W (SSB1) on chromosome IV of Saccharomyces cerevisiae S288c encodes a member of the Hsp70 family of ATP-dependent protein folding chaperones, with ATP hydrolase activity and heat shock protein binding. The gene product is associated with protein folding, import, and quality control, as well as rRNA metabolism, translation, nonsense-mediated mRNA decay, and the ER stress response. It is linked to salinity response, innate immunity, fermentation, and cellular stress responses. Localisation evidence links SSB1 to the cytoplasm, cytosol, nucleus, plasma membrane, and fungal biofilm matrix. Phenotypic associations include increased exponential growth rate, altered chemical resistance, decreased freeze-thaw resistance, abnormal vacuolar morphology, and decreased competitive fitness. Studies of related Hsp70 family members in other species link the family to the non-essential ATPase activity (EC 3.6.4.10) and loss of pathogenicity.