MAF1 — Saccharomyces cerevisiae S288c

Summary

YDR005C (MAF1) in Saccharomyces cerevisiae S288c on chromosome IV encodes a DNA-binding transcription repressor specific for RNA polymerase III, with RNA polymerase III core binding activity. The protein belongs to the Maf1_sf family and localises to the nucleolus, cytoplasm and nucleus. MAF1 is associated with negative regulation of transcription by RNA polymerase III, RNA anabolism, tRNA transcription and decay, translation initiation, ribosome biogenesis, regulation of glucose metabolism, cardiolipin metabolism, dephosphorylation, nuclear import, the isoprenoid pathway and mitochondrial unfolded protein response. Phenotypic associations include decreased sporulation, filamentous growth, biofilm formation, invasive growth, respiratory growth, vegetative growth rate, competitive fitness and stress resistance, increased nucleolus size and RNA accumulation, altered carbon and nitrogen source utilisation, abnormal vacuolar morphology and chemical compound accumulation, and altered chemical resistance. Studies of related genes in other species confirm the family's role in RNA polymerase III regulation.