CDC9 — Saccharomyces cerevisiae S288c

Summary

YDL164C (CDC9) on chromosome IV of Saccharomyces cerevisiae S288c encodes an ATP-dependent DNA ligase, confirmed by DNA ligase (ATP) activity and DNA ligase activity annotations, along with DNA, ATP and metal binding. The gene is associated with lagging strand elongation, Okazaki fragment processing, mitotic recombination, homologous recombination, canonical nonhomologous end joining, nucleotide-excision repair DNA gap filling, mitotic cell cycle progression, nuclear division, S phase, spindle pole body separation, cytokinesis, meiosis, rRNA transcription, and glucose breakdown. It localises to the nucleus, nucleolus, chromatin, nuclear replication fork, DNA ligase IV complex and mitochondria. Phenotypic associations include inviability, abnormal cell cycle progression and S phase, increased mitotic recombination and mutation frequency, decreased sporulation and vegetative growth, increased heat sensitivity, altered chemical resistance, and increased nucleolus size. Studies of related genes in other species link the family to EC 6.5.1.1.