DHH1 — Saccharomyces cerevisiae S288c

Summary

YDL160C in Saccharomyces cerevisiae S288c encodes a protein with RNA helicase activity, ATP hydrolase activity, chromatin binding, and mRNA binding capabilities. The gene is associated with diverse biological processes including pigment anabolism, regulation of autophagy, retrotransposition, gene silencing by miRNA, peroxisomal transport, tRNA nuclear import, RNA and mRNA breakdown, S phase, nucleocytoplasmic transport, protein metabolism, positive regulation of translation, and stem cell renewal. It localizes to the cytoplasmic side of the membrane, P bodies, and stress granules. YDL160C is linked to traits such as zinc sensitivity, potassium concentration, calcium sensitivity, acid sensitivity, and oxidative stress. Phenotypic associations include decreased biofilm formation, abnormal pseudohyphal growth, altered autophagy, decreased mating response, increased apoptosis, decreased invasive growth, increased respiratory growth, decreased fermentative growth, and decreased viability. Related genes in other species link the family to RNA metabolism and translational control.