MSH5 — Saccharomyces cerevisiae S288c

Summary

YDL154W, also known as MSH5, encodes a member of the MutS family of DNA mismatch repair proteins in Saccharomyces cerevisiae. The product binds heteroduplex DNA, Holliday junctions, and mispaired bases, and possesses ATP hydrolase activity. MSH5 is associated with meiotic processes including meiosis I, meiotic mismatch repair, gene conversion, heteroduplex formation, and resolution of recombination intermediates. It is also linked to the maintenance of DNA repeat elements, removal of nonhomologous ends, and mitochondrial DNA repair. The protein localizes to the nucleus, mitochondria, and the MSH2/MSH6 complex. Phenotypically, the gene is associated with decreased meiotic recombination and spore germination, increased filamentous growth and colony sectoring, and altered stress responses including heat sensitivity and starvation resistance. Studies of related genes in other species link the family to the MutSbeta complex.