MBP1 — Saccharomyces cerevisiae S288c

Summary

YDL056W encodes a transcription regulator with DNA-binding transcription repressor, activator, and coactivator activities specific to RNA polymerase II, and belongs to the APSES-type HTH domain family. The gene is associated with ethanol fermentation, pseudohyphal growth, sister chromatid cohesion, steroid metabolism, and cell cycle modulation, and localizes to the SBF and MBF complexes, chromatin, cytoplasm, cytosol, and nucleus. It is linked to traits including protein content and oxidative stress, and phenotypes such as decreased fermentative growth, increased pseudohyphal growth, increased desiccation resistance, altered budding index, decreased respiratory metabolism, increased lifespan, and increased stress resistance. Studies of related genes in other species connect the family to reduced virulence.