DUN1 — Saccharomyces cerevisiae S288c

Summary

YDL101C in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with histone H3S10 kinase activity, Ca2+/calmodulin-dependent kinase activity, and protein kinase A activity, and it binds calmodulin and ATP. The gene is associated with DNA damage checkpoint and repair processes, including double-strand break repair, postreplication repair, nucleotide excision repair, and gene conversion, as well as telomere maintenance, sister chromatid cohesion, and cell cycle checkpoint control. It is linked to responses to gamma radiation, methyl methanesulfonate, and iron, and to deoxyribonucleotide anabolism. The protein localizes to the CPC complex, kinetochore, spindle midzone, and bud neck septin ring. Phenotypic associations include decreased telomere length, increased mutation frequency, reduced replicative lifespan, decreased resistance to UV, oxidative stress, desiccation, and hydrostatic pressure, and abnormal cell cycle progression.