BRE1 — Saccharomyces cerevisiae S288c

Summary

YDL074C, also known as BRE1 in Saccharomyces cerevisiae S288c, encodes a RING-type E3 ubiquitin ligase that binds scaffold proteins, DNA replication origins, and identical proteins, and possesses histone H2BK120 ubiquitin ligase activity. The protein localizes to the nucleus, particularly the HULC complex and telomeric regions. YDL074C is associated with protein ubiquitination, chromatin and telomeric silencing, cell cycle checkpoints, DNA damage response, telomere maintenance, sister chromatid cohesion, and cellular senescence. It is linked to numerous phenotypes including absent silencing, abnormal meiosis, decreased telomere length, reduced replicative and chronological lifespan, increased cell size, altered cell cycle progression, and sensitivity to oxidative stress, light, acid, and freeze-thaw conditions. The gene is also connected to leaf shape and RNA processing. Studies of related genes in other species link them to ubiquitin ligase activity (EC 2.3.2.27).