CDC7 — Saccharomyces cerevisiae S288c

Summary

YDL017W in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with RNA Polymerase II CTD heptapeptide repeat kinase activity and CDK activity, belonging to the Ser/Thr kinase and protein kinase domain families. The gene is associated with adenine anabolism, chitin anabolism, cell cycle progression through the G1/S phase transition, mitotic cell cycle, meiosis I, spindle assembly, nuclear division, and regulation of mRNA splicing via the spliceosome. It is linked to cell polarity establishment, DNA metabolism, and zygotic genome activation. Localization evidence connects the product to the cellular bud neck, division septum, mitotic spindle pole body, chromatin, and nucleolus. Phenotypic associations include arrested meiosis and cell cycle, increased chitin deposition, altered mutation frequency, increased thermotolerance, decreased UV resistance, abnormal cellular morphology, and reduced vegetative growth. The gene is also linked to oxidative stress and increased resistance to chemicals.