TUP1 — Saccharomyces cerevisiae S288c

Summary

YCR084C, also known as TUP1, encodes a transcriptional corepressor in Saccharomyces cerevisiae S288c. The protein contains an N-terminal repression domain and WD40 repeats, and it has DNA-binding transcription repressor activity and transcription corepressor activity. It binds histones, mediator complex components, and histone deacetylases, and acts as a ubiquitin ligase substrate adaptor. TUP1 is associated with numerous biological processes including glucose metabolism, flocculation, cell wall biogenesis, biofilm formation, ER stress response, cellular homeostasis, polar cell growth, and chitin anabolism. It localizes to the nucleus, cytoplasm, and chromatin as part of transcription repressor complexes. The gene is linked to traits such as biomass yield, protein content, potassium concentration, oxidative stress, and acid sensitivity. Phenotypic associations include increased flocculation, altered cell cycle progression, decreased replicative lifespan, and abnormal cellular morphology.