PDI1 — Saccharomyces cerevisiae S288c

Summary

YCL043C, also known as PDI1, encodes a protein with protein-disulfide reductase activity and unfolded protein binding, and is associated with disulphide bond formation in the ER lumen of Saccharomyces cerevisiae. This gene is associated with protein folding, maturation, and processing in the endoplasmic reticulum, as well as the ERAD pathway and ER stress response. PDI1 is linked to alkaloid anabolism, including ergot alkaloid and MIA pathway processes, and to secretion, translational attenuation, spore germination, and intracellular signal transduction. It has been linked to oxidative stress response and cellular responses to DTT. Phenotypic associations include decreased vegetative growth rate, increased heat sensitivity, delayed endocytosis, decreased protein activity, altered protein accumulation, decreased starvation resistance and competitive fitness, and altered chemical resistance. Studies of related genes in other species link the family to protein disulfide-isomerase activity (EC 5.3.4.1).