HIS4 — Saccharomyces cerevisiae S288c

Summary

YCL030C, also known as HIS4 on chromosome III of Saccharomyces cerevisiae S288c, encodes a trifunctional enzyme with phosphoribosyl-ATP diphosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities, and it binds NAD, ATP, and metals. The gene is associated with histidine anabolism and metabolism, as well as responses to UV-B and UV-A, amino acid starvation, and processes including nitrogen fixation, melibiose metabolism, isoleucine anabolism, meiotic gene conversion, heteroduplex formation, recombination within rDNA repeats, mRNA destabilization, plasmid maintenance, chromosome separation, and second meiotic division. It localizes to the cytoplasm, cytosol, and nucleus. The gene is linked to traits such as potassium uptake and oxidative stress, and phenotypes including auxotrophy, decreased heat sensitivity, altered metal and chemical resistance, increased chemical compound accumulation, abnormal vacuolar morphology, and decreased competitive fitness. Studies of related genes in other species link the family to histidinol dehydrogenase and phosphoribosyl-ATP diphosphatase activities.