CHK1 — Saccharomyces cerevisiae S288c

Summary

YBR274W (CHK1) on chromosome II of Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with histone H3S10 kinase activity, Ca2+/CaM-dependent kinase activity, calmodulin binding, phospholipid binding, and ATP binding. The gene is associated with the DNA damage checkpoint, non-homologous end joining (NHEJ), base excision repair (BER), postreplication repair, sumoylation, mitotic exit, downregulation of DNA replication, and response to camptothecin and cisplatin. It is linked to the chromosomal passenger complex (CPC), the meiotic spindle midzone, inner kinetochore, spindle microtubules, and the septin ring. Associations with traits include protein content and oxidative stress, and phenotypes include abnormal cell cycle progression through the G2/M phase transition, decreased apoptosis, increased mutation frequency, decreased vegetative growth, and altered resistance to chemicals. Studies of related genes in other species link the family to calcium sensitivity.