PAF1 — Saccharomyces cerevisiae S288c

Summary

YBR279W, also known as PAF1, is a gene on chromosome II of Saccharomyces cerevisiae S288c that encodes a component of the Paf1 complex, a protein that binds RNA polymerase II and chromatin. The gene is associated with a wide range of biological processes, including regulation of anabolism, mRNA 3'-end processing, the MAPK cascade, mitophagy, vacuole fusion, telomere maintenance, and response to stress. It has been linked to numerous traits and phenotypes, such as decreased anaerobic and respiratory growth, increased cold sensitivity, altered cell size and bud morphology, increased replicative lifespan, and decreased chronological lifespan. Associations also include potassium concentration, calcium and acid sensitivity, and increased oxidative stress resistance. The Paf1 protein localises to the nucleus and cytosol. Studies of related genes in other species, such as the RNA polymerase II-associated protein 1 homolog, further connect this family to transcriptional regulation.