ISW1 — Saccharomyces cerevisiae S288c

Summary

YBR245C (ISW1) on chromosome II of Saccharomyces cerevisiae S288c encodes an ATP-dependent chromatin remodeler with histone octamer slider, nucleosome array spacer, DNA translocase, helicase, and histone carrier activities, and binds nucleosomes, chromatin, centromeres, TBP-class proteins, and single-stranded DNA. The gene is associated with DNA damage checkpoint and response, double-strand break processing, regulation of RNA polymerase II transcription preinitiation complex assembly, chromatin organization, nucleosome organization, heterochromatin boundary formation, replication-dependent chromatin assembly, negative regulation of antisense RNA transcription, S phase, rRNA processing, methylation, sulfur amino acid and membrane lipid anabolism, chitin metabolism, and cellular pheromone response. It localizes to the SHREC complex, nuclear microtubule, transcription regulator complex, CENP-A-containing chromatin, SWI-SNF and PBAF complexes, and heterochromatin islands. Phenotypic associations include increased heat sensitivity, decreased silencing, increased mutation frequency, abnormal chromosome maintenance, increased innate thermotolerance, altered stress and toxin resistance, and decreased competitive fitness.