ATG12 — Saccharomyces cerevisiae S288c

Summary

YBR217W, also known as ATG12 in Saccharomyces cerevisiae S288c, encodes a ubiquitin-like protein with APG8 ligase activity, protein tag activity, and enzyme activator activity. It is a component of the Atg12-Atg5-Atg16 complex and localises to the PAS membrane and cytosol. The gene is associated with macroautophagy, micropexophagy, nucleophagy, glycophagy, mitophagy, and the cytoplasm-to-vacuole targeting (Cvt) pathway, as well as vesicle formation, protein lipidation, and response to starvation. YBR217W is linked to catabolism, protein breakdown, membrane lipid and sulfur amino acid anabolism, mating, phagocytosis, and protein unfolding. Phenotypically, its disruption is associated with absent or decreased autophagy, mitophagy, and reticulophagy, abnormal vacuolar and nuclear morphology, decreased viability, sporulation defects, decreased stress and desiccation resistance, increased metal and toxin resistance, altered protein modification and accumulation, and decreased chronological lifespan. It is also associated with phosphate content and oxidative stress.