IRA1 — Saccharomyces cerevisiae S288c

Summary

YBR140C in Saccharomyces cerevisiae S288c encodes a protein with GTPase-activating protein (GAP) activity. The gene is associated with glycogen metabolism and anabolism, as well as a wide range of transport processes including histidine, tyrosine, lysine, phenylalanine, glutamine, and leucine transport, along with regulation of amino acid transport and downregulation of endocytosis and Ras protein signal transduction. It is linked to MAPK cascade, phototropism, penetration peg formation, proline breakdown, dephosphorylation, and regulated exocytosis. The protein localises to the cytosol, nucleus, cell cortex, mating projection, division septum, and cortical dynamic polarity patch. YBR140C is associated with traits including nitrogen content, potassium uptake, and acid sensitivity, and with phenotypes such as decreased sporulation, vegetative growth, starvation resistance, and thermotolerance, as well as increased invasive growth, pseudohyphal growth, and adhesion. The gene is related to IRA1.