UBC4 — Saccharomyces cerevisiae S288c

Summary

YBR082C in Saccharomyces cerevisiae S288c encodes a ubiquitin-conjugating enzyme with ubiquitin-conjugating enzyme activity, ubiquitin-protein transferase activity, ubiquitin ligase activity, ssDNA-dependent ATPase activity, and proteasome binding. It is associated with protein autoubiquitination, ubiquitin recycling, protein destabilization and breakdown, the stress-induced homeostatically regulated protein degradation pathway, and K63-linked ubiquitination. The gene is linked to cell communication, the G0 to G1 transition, filamentous growth, DNA damage response, leaf senescence, fruit ripening, translation elongation, protein folding, and responses to zinc including zinc import. It localizes to the nucleus, cytoplasm, cytosol, telomeric regions, and several ubiquitin ligase complexes including Rad6-Rad18, UBR1-RAD6, and MUB1-RAD6-UBR2. Phenotypic associations include increased lifespan, increased chronological lifespan, increased oxidative stress resistance, increased mating response and pheromone sensitivity, decreased UV resistance, decreased heat sensitivity, decreased toxin resistance, decreased vegetative growth rate, and decreased competitive fitness.