MMS4 — Saccharomyces cerevisiae S288c

Summary

YBR098W (EME1, MMS4) on chromosome II of Saccharomyces cerevisiae S288c encodes a protein with endodeoxyribonuclease RUS activity, endonuclease activity, DNA binding, and metal binding, belonging to the Mms4/EME1/EME2 family and containing an ERCC4 domain. The gene is associated with homologous recombination repair, gene conversion, mismatch repair, nucleotide excision repair, DNA damage checkpoint, cell cycle checkpoint, meiosis I, prophase, nuclear division, sister chromatid cohesion, telomere maintenance, DNA topological change, and DNA metabolism. It is also linked to the multivesicular body sorting pathway, ubiquitin-dependent protein catabolism via the MVB pathway, and aromatic amino acid family anabolism. The protein localises to the resolvasome and nucleus. Phenotypic associations include decreased resistance to X-rays, gamma rays, UV, oxidative stress, and desiccation, increased mutation frequency, decreased sporulation and viability, and altered competitive fitness. Studies of related genes in other species link the family to endodeoxyribonuclease activity (EC 3.1.22.-).