PHO5 — Saccharomyces cerevisiae S288c

Summary

YBR093C (PHO5) on chromosome II of Saccharomyces cerevisiae S288c encodes an acid phosphatase with 4-phytase, 3-phytase, and thiamin monophosphatase activities. The protein belongs to the histidine acid phosphatase family and is localised to the cell wall-bounded periplasmic space, fungal-type cell wall, and extracellular space. PHO5 is associated with cellular response to phosphate starvation, phosphate homeostasis, organophosphate and polyphosphate breakdown, thiamine salvage and metabolism, RNA anabolism and processing, translation elongation, protein folding, cell cycle modulation, and amylase release. The gene is linked to traits including phosphorus concentration, carbohydrate content, oxidative stress, and light sensitivity. Phenotypic associations include altered mating response, prion formation, chitin deposition, bud morphology, cell size, heat sensitivity, stress resistance, nitrogen source utilisation, metal resistance, competitive fitness, vegetative growth, vacuolar morphology, and chemical resistance. Studies of related genes in other species link the family to reduced virulence.