SEC18 — Saccharomyces cerevisiae S288c

Summary

YBR080C, also known as SEC18, encodes an ATP-dependent protein disaggregase with ATP hydrolase activity, capable of binding phosphatidate, SNAREs, and polyubiquitin-modified proteins. This gene is associated with numerous cellular processes including secretion, ER-to-Golgi transport, vesicle fusion with the Golgi apparatus, SNARE complex disassembly, membrane assembly, glycoprotein transport, regulated exocytosis, ergosterol anabolism, and micropexophagy. It is associated with protein breakdown, morphogenesis, and the activation of cellular responses to hypoxic stress. The encoded protein localizes to the Golgi stack, cytoplasm, peroxisome membrane, and several protein complexes including the p97-Ufd1-Npl4 and Hrd1p ubiquitin ligase complexes. Phenotypic associations include absent or decreased protein secretion, abnormal endomembrane system morphology, decreased autophagy, decreased filamentous and invasive growth, and inviability. Studies of related genes in other species connect the family to AAA ATPase activity (EC 3.6.4.6).