CHS3 — Saccharomyces cerevisiae S288c

Summary

YBR023C in Saccharomyces cerevisiae S288c encodes a protein with chitin synthase activity. The gene is associated with a wide range of biological processes, including chitin, mannan, and glucan anabolism, protein palmitoylation and mannosylation, spore wall assembly, and cell wall assembly. It localizes to the chitosome, cell periphery, bud neck, and plasma membrane. Phenotypic associations link YBR023C to decreased chitin deposition, abnormal spore wall formation and cell wall morphology, increased vegetative growth and biofilm formation, decreased mating efficiency and sporulation, and altered stress resistance, including increased heat sensitivity and decreased UV and metal resistance. The gene is also connected to traits such as polysaccharide and sugar content, biomass yield, and oxidative stress. Studies of related genes in other species link the family to reduced virulence.