SEC17 — Saccharomyces cerevisiae S288c

Summary

YBL050W (SEC17) on chromosome II of Saccharomyces cerevisiae encodes a SNAP protein with syntaxin-binding and ATPase activator activity. The gene product is associated with SNARE complex disassembly and is linked to multiple membrane trafficking processes, including ER-to-Golgi transport, vesicle fusion with the Golgi apparatus, homotypic vacuole fusion, and protein secretion. SEC17 localizes to the SNARE complex, vacuolar membrane, and cytosol, and is associated with ceramide transport, glycosylation, protein palmitoylation, and micropexophagy. Phenotypic associations include arrested vegetative growth, decreased protein secretion and nutrient uptake, abnormal endomembrane system and vacuolar morphology, increased invasive growth, and altered chemical resistance. The gene is also associated with hormone secretion, neurotransmitter release, and glucose import, with loss-of-function resulting in inviability or haploinsufficiency.