UBP13 — Saccharomyces cerevisiae S288c

Summary

YBL067C (creB, UBP13) on chromosome II of Saccharomyces cerevisiae S288c encodes a metal-dependent deubiquitinase with thiol-dependent deubiquitinase activity, belonging to the peptidase C19 and ubiquitin-specific protease families. The gene is associated with carbon catabolite repression of transcription, ubiquitin-dependent proteolysis, response to stress, response to cAMP, and activation of CREB. It is linked to mitochondrial biogenesis, protein folding, and regulation of binding, as well as viral transcription and the lytic switch. Localization evidence connects the product to the cytosol, nucleus, cell tip, and cell division site. Phenotypic associations include decreased competitive fitness, respiratory growth, and stress resistance, along with altered toxin resistance, abnormal vacuolar morphology, and decreased biofilm formation. Studies of related genes in other species link the family to ubiquitin-dependent processes.