PKC1 — Saccharomyces cerevisiae S288c

Summary

YBL105C, also known as PKC1, encodes a protein with protein serine/threonine kinase activity, ATP binding, zinc binding, and lipid binding capabilities. It is associated with cell wall organization, the MAPK cascade, TORC1 signaling, mitophagy, pexophagy, plasma membrane repair, and responses to miconazole and amino acids. The gene is linked to 1,3-beta-glucan, glucan, and alpha-glucan anabolism, as well as glycerolipid anabolism, DNA metabolism, mitotic recombination, and the electron transport chain. PKC1 localizes to the site of polarized growth, cell tip, division septum, cross wall, stress granule, cytoskeleton, cytoplasm, and nucleus. Phenotypic associations include increased cell size, arrested cell cycle progression, abnormal actin cytoskeleton morphology, increased heat sensitivity, altered toxin resistance, and decreased vegetative growth. Studies of related genes in other species link the family to protein kinase C-like activity and unaffected pathogenicity.