HAP3 — Saccharomyces cerevisiae S288c

Summary

YBL021C in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with RNA polymerase II-specific activator activity, also annotated for TBP-class protein binding, protein heterodimerization activity, and GTF2 activity. The protein belongs to the HAP3/NFYB family and contains a histone-fold domain. It is associated with the CCAAT-binding factor complex and negative cofactor 2 complex, localizes to the nucleus, cytosol, and chromatin, and is linked to numerous biological processes including cytochrome and heme biosynthesis, the TCA cycle, glutamate and lysine biosynthesis, phospholipid homeostasis, carbon and nitrogen catabolite repression, replicative senescence, and translation. Phenotypic associations include altered respiratory growth, decreased chronological lifespan, increased mitochondrial mutation frequency, abnormal sporulation and vacuolar morphology, and altered stress resistance. Studies of related genes in other species link the family to similar regulatory roles.