RFA1 — Saccharomyces cerevisiae S288c

Summary

YAR007C (RFA1) on chromosome I of Saccharomyces cerevisiae S288c encodes a protein with domains including Euk_RPA1_DBD_C, REPA_OB_2, Rep_factor-A_N, Rep_factor-A_C, NA-bd_OB_tRNA, and NA-bd_OB-fold. It is annotated with telomerase RNA binding, telomeric ssDNA binding, telomere binding, damaged DNA binding, ssDNA binding, and zinc binding. RFA1 is associated with telomere maintenance, DNA damage checkpoint control, recombinational repair, mating-type switching, gene conversion, transposition, S-M checkpoint, response to UV and UV-A, and many other biological processes. It localises to sites of DNA damage, double-strand breaks, telomeric repeat regions, chromatin, the RPA complex, cytoplasm, cytosol, and nucleus, and is linked to nuclear import and export. Phenotypically, RFA1 has been connected to decreased telomere length, increased mutation frequency, reduced UV resistance, abnormal cell cycle progression and chromosome segregation, altered budding and spindle morphology, decreased vegetative growth, and changes in chemical and toxin resistance.