SSA1 (YAL005C) — Saccharomyces cerevisiae S288c

Summary

YAL005C (SSA1) in Saccharomyces cerevisiae encodes an ATP-dependent protein folding chaperone of the Hsp70 family, with ATP hydrolase activity and binding capabilities for peptides, unfolded proteins, and heat shock proteins. It also acts as a transcriptional co-regulator. The gene is associated with protein refolding, stress response, biofilm formation, invasive growth, cell communication, and memory. It has been linked to protein content, oxidative stress, and numerous phenotypes including increased heat sensitivity, decreased UV and toxin resistance, altered colony shape and appearance, increased chronological lifespan, delayed G1/S cell cycle progression, and both increased and decreased competitive fitness. The encoded protein localizes to the cell wall, plasma membrane, extracellular region, and protein aggregate centers. Studies of related genes in other species link this gene family to general chaperone functions.