ROX1 — Saccharomyces cerevisiae S288c

Summary

YPR065W, also known as RFG1 or ROX1 on chromosome XVI of Saccharomyces cerevisiae S288c, encodes a DNA-binding transcription activator with RNA polymerase II-specific activity, belonging to the SRY-related HMG-box transcription factor family. The gene is associated with hemoglobin breakdown, lycopene and ergosterol anabolism, response to anoxia, sterol depletion, cold, and DNA damage, as well as cell cycle modulation, morphogenesis, protein folding, detoxification, and filamentous growth regulation. It localizes to the nucleus. Phenotypic associations include decreased anaerobic and respiratory growth, altered stress resistance (e.g., increased oxidative stress resistance but decreased general stress resistance), altered metal and chemical resistance, delayed G1 phase progression, decreased mating response, and variable effects on competitive fitness and vegetative growth. Related genes in other species are linked to additional regulatory roles.