RHO1 — Saccharomyces cerevisiae S288c

Summary

YPR165W, also known as RHO1, encodes a small GTPase of the Rho family, possessing GTPase activity, GTP and GDP binding, protein kinase binding, and signaling adaptor activity. In Saccharomyces cerevisiae, RHO1 is associated with cell morphogenesis, the MAPK cascade, exocytosis, exocyst localization, secretion, cell wall beta-glucan anabolism and its regulation, bipolar cell growth, regulation of actomyosin contractile ring contraction, primary cell septum hydrolysis, cleavage furrow ingression, and ruffle assembly. It localizes to sites of polarized growth, the exocytic vesicle, cleavage furrow, and the Cdc42 GTPase complex. The gene is linked to acid sensitivity and oxidative stress, and its disruption is associated with decreased cytokinesis, increased cell death, G2/M phase arrest, abnormal actin cytoskeleton morphology, increased cell size, decreased vegetative growth, increased heat sensitivity, and inviability. Studies of related genes in other species link the family to loss of pathogenicity.