PRE2 — Saccharomyces cerevisiae S288c

Summary

YPR103W encodes a threonine endopeptidase, a beta-subunit of the proteasome core complex, and belongs to the peptidase T1A subfamily. The gene is associated with proteolysis and protein catabolic processes, 20S proteasome assembly, and is localized to the proteasome core complex, nucleus, cytoplasm, and nuclear envelope. It is linked to antigen processing, immune response, response to starvation, detection of pheromone, mitosis, and various metabolic processes including sulfur amino acid metabolism, biotin anabolism, methanol metabolism, fatty acid oxidation, and CoA metabolism. Phenotypic associations include abnormal cell cycle progression, decreased telomere length, increased mutation frequency, decreased UV and toxin resistance, increased heat sensitivity, decreased vegetative growth and competitive fitness, and altered resistance to chemicals. Studies of related genes in other species link the family to protein content traits.