CLB5 — Saccharomyces cerevisiae S288c

Summary

YPR120C, also known as CLB2 or CLB5, is a gene on chromosome XVI of Saccharomyces cerevisiae S288c. It encodes a cyclin, a protein with cyclin-dependent protein serine/threonine kinase activator activity and regulator activity, and protein kinase activity. The gene is associated with chromosome separation, spindle elongation, DNA recombination, spindle assembly checkpoint, regulation of spore germination, mitotic cell cycle, cell cycle checkpoint, protein secretion, pheromone response, metaphase, meiotic M phase, M phase, spindle assembly, embryonic cleavage, nuclear division, G1 phase, import into cell, and mitotic cell cycle phase transition. The encoded cyclin localizes to the microtubule-organizing center, spindle pole bodies, the mitotic spindle midzone, and the nucleoplasm. Phenotypic associations include altered cell cycle progression, increased cell size, decreased sporulation and vegetative growth, reduced replicative lifespan, increased mutation frequency, and heightened sensitivity to heat and UV.