TEF1 — Saccharomyces cerevisiae S288c

Summary

YPR080W (TEF1) on Saccharomyces cerevisiae chromosome XVI encodes a protein with translation elongation factor activity, GTPase activity, GTP binding, and calmodulin binding. The gene is associated with translation elongation, cytoplasmic translational elongation, regulation of RNA anabolism, 1-butanol metabolism, glycerol breakdown, glutathione breakdown, ethanol anabolism, riboflavin anabolism, mRNA pseudouridylation, mRNA capping, tRNA charging, tRNA transcription, tRNA decay, fatty acid beta-oxidation, and host invasion. The product localises to the eukaryotic translation elongation factor 1 complex, cytoplasm, cytosol, and cell wall (yeast-form, hyphal, and fungal-type). Associations with increased cell size, increased heat sensitivity, decreased vegetative growth rate, abnormal actin cytoskeleton morphology, and oxidative stress have been noted. Related genes in other species link the family to translation elongation.