ARP7 — Saccharomyces cerevisiae S288c

Summary

YPR034W (ARP4, ARP7) on chromosome XVI of Saccharomyces cerevisiae S288c encodes an actin-related protein that binds histones, chromatin, and ATP. The product is a component of multiple chromatin-modifying complexes, including SWI-SNF, INO80, SWR-C, TIP60, and the H4/H2A HAT complex, and is also associated with the dynactin and dynein complexes and microtubules. ARP4 is linked to chromatin modeling, DNA replication, DNA repair-dependent chromatin remodeling, kinetochore assembly, chromosome condensation, rRNA transcription, and nucleus organization. It has been connected to nitrogen catabolite repression, catabolite repression, regulation of cell growth, and transposition. Phenotypic associations include abnormal nucleolar and mitochondrial morphology, altered carbon source utilization, increased heat sensitivity, decreased vegetative growth and competitive fitness, and altered chemical resistance.