CLN2 — Saccharomyces cerevisiae S288c

Summary

YPL256C in Saccharomyces cerevisiae S288c encodes a cyclin-dependent protein serine/threonine kinase regulator, belonging to the cyclin CLN family. It is associated with cell cycle G1/S phase transition, regulation of G1/S transition of the mitotic cell cycle, cell cycle checkpoint, and regulation of kinase activity. The gene is linked to chitin anabolism, biofilm formation, pseudohyphal and invasive growth, response to nutrient and peptide stimuli, and regulation of cell morphogenesis. It localizes to the CDK holoenzyme complex, cytoplasm, cytosol, and nucleus. Associations include traits such as calcium sensitivity, protein content, and oxidative stress, as well as phenotypes affecting cell cycle progression, cell size, invasive growth, endocytosis, UV resistance, starvation resistance, chronological lifespan, vegetative growth, and competitive fitness. Studies of related genes in other species link the family to reduced virulence.