IPL1 — Saccharomyces cerevisiae S288c

Summary

YPL209C in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with histone H3S10 kinase activity, ATP binding, and lipid binding, belonging to the Aurora-like kinase family. It is associated with chromosome biorientation, spindle assembly and organization, spindle pole body assembly, microtubule assembly, and the spindle assembly checkpoint. The gene is linked to meiosis I and II, metaphase, nuclear transport, and response to glucose. Its product localizes to the kinetochore microtubule, spindle midzone, spindle pole, and the CPC complex. YPL209C is associated with increased aneuploidy and polyploidy, abnormal chromosome segregation, decreased vegetative growth, increased heat sensitivity, decreased competitive fitness, and altered chemical resistance. Related genes in other species link the family to similar chromosome segregation processes.