HSP82 — Saccharomyces cerevisiae S288c

Summary

YPL240C (HSP82) on chromosome XVI of Saccharomyces cerevisiae S288c encodes the ATP-dependent protein folding chaperone Hsp90, a member of the heat shock protein 90 family characterized by Hsp90_N, Hsp90_C, and HATPase_C domains. The gene product is associated with mitochondrial fission, programmed cell death, the intrinsic apoptotic pathway, non-homologous end joining, cell wall biogenesis, and responses to abiotic stimuli including thermal and osmotic stress. It has been linked to traits such as germination rate, salt sensitivity, and oxidative stress, and to phenotypes including decreased vegetative growth, increased heat and cold sensitivity, reduced chronological lifespan, abnormal cellular and nuclear morphology, impaired respiratory metabolism, and decreased competitive fitness. Related genes in other species link the family to steroid hormone receptor signaling and telomere maintenance via telomerase.