NAB3 — Saccharomyces cerevisiae S288c

Summary

YPL190C, also known as NAB3, encodes a protein with an RRM domain and a Nab3-specific RRM subfamily domain, with poly-A binding molecular function. In Saccharomyces cerevisiae, this nuclear-localized gene is associated with RNA surveillance, RNA processing, transcriptional attenuation, and mRNA transcription, as well as with cellular response to nutrient, cell cycle modulation, and flocculation. It has been linked to traits including amino acid content and oxidative stress, and to phenotypes such as decreased cell cycle progression through the G2/M phase transition, abnormal redox state, decreased chromosome/plasmid maintenance, increased mitotic recombination, decreased nucleolus size, decreased silencing, increased heat sensitivity, decreased vegetative growth, and decreased competitive fitness. Studies of related genes in other species link the family to nuclear receptor coactivation.