DBP1 — Saccharomyces cerevisiae S288c

Summary

YPL119C encodes a DEAD-box RNA helicase in Saccharomyces cerevisiae S288c. The protein possesses ATP hydrolase activity, RNA helicase activity, and translation initiation factor activity, and binds ATP, mRNA, and G-quadruplex structures. It localizes to the cytoplasm, nucleus, stress granules, and the spliceosome complex. YPL119C is associated with cytoplasmic translational initiation, regulation of translation, RNP complex assembly, spliceosome disassembly, and RNA transport. It is linked to cell growth, the cell cycle, replicative senescence, and oxidative stress. Phenotypic associations include altered chronological lifespan, decreased vegetative growth, abnormal vacuolar morphology, and changes in chemical resistance and metal resistance. The gene is also associated with sugar content and innate immunity. Related genes in other species link the family to RNA-dependent processes.